Tolysin in Subacute Rheumatic
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چکیده
Tolysin, which is the ethyl ester of para methylphenyl cinchoninic acid, has recently been added to the list of remedies said to be useful in rheumatic fever. In the present study the effect of this drug was observed2 in cases of juvenile rheumatic fever, in which it is well known that joint symptoms are often minimal and that the carditis may be the most prominent feature. Its antipyretic and analgesic action in acute arthritis has been frequently observed and has been reviewed by Hanzlik (1). Of the many workers cited by him, Barbour, Lozinsky and Clements (2), and Miller and Boots (3) have in particular, given instances of the satisfactory clinical action of tolysin on the acute phases of this disease. The latter authors present among their cases four of juvenile rheumatic feverwith serious cardiac involvement but little or no arthritis, which are somewhat similar to the cases reported in this paper. Poynton (4) has been favorably impressed by its effects in children with rheumatic carditis. The action of salicyl in rheumatic fever, including its effects on the cardiac manifestations, has been extensively studied and is completely described by Hanzlik as mentioned above.. From this review we quote a few words concerning the relationship of the salicylates and cincophen, which summarize our knowledge of the pharmacology of these .drugs, although the statement about the absorbability of neocincophen might have to be revised since the recent work of Spurling and Hartman (10).
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تاریخ انتشار 2013